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Drug Usage Trend study

Introduction to Drug Usage Trend study:

The "Usage Trend Study" looks in to various products' awareness, usage, satisfaction, product image and future usage expectations (increase/stay the same/decrease). This study was first started in 1984 as "Drug Usage and Satisfaction Study" via postal survey, and have been conducted over 40 times. In December 2006, the study was updated to the current methodology (online).

This study currently covers 10 therapeutic areas (drug types):
  1. Anti-hypertensive drugs*
  2. Anti-hyperlipidemia drugs*
  3. Antibiotics*
  4. Anti-rheumatic arthritis drugs*
  5. Oral non steroid anti-inflammatory drugs; NSAIDs*
  6. Patch/tape non steroid anti-inflammatory drugs; NSAIDs*
  7. Anti-allergy drugs (from Oct. 2007)**
  8. BPH / urinary disorder treatment drugs (from Oct. 2007)**
  9. Antiplatelets (from Jan. 2008)***
  10. a.Osteoporosis drugs (from Jan. 2008)***
    • *For the above 6 therapeutic types (a-f), past studies were conducted in Dec. 2006, Oct. 2007, May 2008, Nov. 2008.
    • **For the above 2 therapeutic types (g & h), past studies were conducted in Oct. 2007, May 2008, Nov. 2008.
    • ***For the above 2 therapeutic types (i & j), past studies were conducted in Jan. 2008, Aug. 2008, Feb. 2009.
    • Studies for above 8 therapeutic types (a-h) are underway for May 2009.

Outline of Drug usage trend study:

  1. Project name: Drug usage trend study
  2. Objective: To quantitatively understand the awareness, usage, product image, satisfaction and future usage intensions of various products.
  3. Methodology: Online survey (since Dec. 2006)
  4. Survey region: Nationwide
  5. Sample size: (differs depending on therapeutic area: see below for breakdown)

  Hyper-tension Hyper-lipidemia Antibiotics Oral NSAIDs Patch NSAIDs RA Allergy BPH Anti-platelets Osteo-porosis
General IM 263 257 257 264 264 258 255 261 265 270
Gastroenterologists 53 53                
Cardiologists 58 55             52 54
Endocrinologists 55 58                
Nephrologists 34 33                
Neurologists                 50 50
Pulmonologists     62       59      
Rheumatologists       34 34 36        
Surgeons     100 101 101       100 101
Orthopedics       102 102 102     98 101
Brain surgeons 54 53             52 53
Dermatologists     63       65      
ENT     65       63      
Urologists     104         104    
TOTAL (n=) 517 509 651 501 501 396 442 365 617 629
*Sample from latest version (Feb. 2009 for antiplatelets and osteoporosis / Nov. 2008 version for rest)

Contents of Drug usage trend study:

For each area, the study topics include:
  • Awareness and usage of specific drugs (see list below)
    • Allows you to see the product's share within the therapeutic area, and also the trend by looking at the past results
    • Also it covers the reasons for using each product
  • Product image
    • Each product is evaluated by various attributes (such as "strong efficacy" "long duration of effect" etc.) so that you can understand how products are positioned by the physicians.
  • Product satisfaction
    • Each product is evaluated numerically in terms of satisfaction levels (efficacy and safety).
  • Future usage expectations
    • Respondents are asked about their expected use of each product in 6 months time (increase, decrease, stay same, discontinue etc.).
    • For products they intend to switch (use less/discontinue), they are asked to which products they will switch to (including generics), and also the reason for why they intend to switch to that drug.

Product list for each area:
Anti-hypertensive drugs (Nov. 2008 version)
  • Renivace (enalapril): Banyu
  • Renivace (enalapril): Banyu
  • Tanatril (imidapril): Mitsubishi-Tanabe
  • Acecol (temocapril): Daiichi-Sankyo
  • Coversyl (perindopril): Kyowa-Kirin
  • Olmetec (olmesartan): Daiichi-Sankyo/Kowa
  • Diovan (valsartan): Novartis
  • Nu-Lotan (losartan): Banyu
  • Blopress (candesartan): Takeda
  • Micardis (telmisartan): Boehringer Ingelheim/Astellas
  • Irbetan (irbesartan): Shionogi
  • Avapro (irbesartan): Dainippon-Sumitomo
  • Preminent (losartan): Banyu
  • Norvasc (amlodipine): Pfizer
  • Amlodin (amlodipine): Dainippon-Sumitomo
  • Amlodin OD (amlodipine): Dainippon-Sumitomo
  • Adalat CR (nifedipine): Bayer
  • Coniel (benidipine): Kyowa-Kirin
  • Herbesser R (diltiazem): Mitsubishi-Tanabe
  • Atelec (cilnidipine): Mochida
  • Calblock (azelnidipine): Daiichi-Sankyo
  • Cardenalin (doxazosin): Pfizer
  • Artist (carvedilol): Daiichi-Sankyo
  • Maintate (bisoprolol): Mitsubishi-Tanabe
  • Tenormin (atenolol): AstraZeneca/ Dainippon-Sumitomo
  • Selara (eplerenone): Pfizer
Anti-hyperlipidemia drugs (Nov. 2008 version)
  • Mevalotin (pravastatin): Daiichi-Sankyo
  • Lipitor (atorvastatin): Astellas/Pfizer
  • Lipovas (simvastatin): Banyu
  • Lochol (fluvastatin): Novartis
  • Crestor (rosuvastatin): AstraZeneca/Shionogi
  • Livalo (pitavastatin): Daiichi-Sankyo/Kowa
  • Lipidil (fenofibrate): Takeda/Kaken/Asuka
  • Tricor (fenofibrate): Teijin
  • Bezatol SR (bezafibrate): Kissei
  • cholebine (colestilan): Mitsubishi-Tanabe
  • Epadel (ethyl icosapentate): Mochida
  • Zetia (ezetimibe): Schering-Plough
Antibiotics (Nov. 2008 version)
  • Flomox (cefcapene pivoxil): Shionogi
  • Cefzon (cefdinir): Astellas
  • Meiact (cefditoren): Meiji
  • Cravit (levofloxacin): Daiichi-Sankyo
  • Gatiflo (gatifloxacin): Kyorin/Dainippon-Sumitomo
  • Avelox (moxifloxacin): Bayer/Shionogi
  • Geninax (garenoxacin): Astellas/ Taisho-Toyama
  • Clarith (clarithromycin): Taisho-Toyama
  • Klaricid (clarithromycin): Abbott
  • Zithromac (azithromycin): Pfizer
Anti-rheumatic arthritis drugs (Nov. 2008 version)
  • Rheumatrex (methotrexate): Wyeth/Takeda
  • Rimatil (bucillamine): Santen
  • Azulfidine EN (sulfasalazine): Santen/Pfizer
  • Enbrel (etanercept): Wyeth/Takeda
  • Remicade (infliximab): Mitsubishi-Tanabe
  • Arava (leflunomide): Sanofi Aventis
  • Prograf (tacrolimus): Astellas
  • Actemra (tocilizumab): Chugai
  • Humira (adalimumab): Abbott/Eisai
  • Methotrexate Tanabe (MTX): Mitsubishi-Tanabe
  • Methotrexate Sawai (MTX): Sawai
  • Metolate (MTX): Santen
Oral non steroid anti-inflammatory drugs; NSAIDs (Nov. 2008 version)
  • Loxonin (loxoprofen): Daiichi-Sankyo
  • Voltaren (diclofenac): Novartis
  • Osteluc (etodolac): Wyeth/Takeda
  • Mobic (meloxicam): Daiichi-Sanky
  • Hypen (etodolac): Nippon-Shinyaku
  • Lorcam (Lornoxicam): Taisho-Toyama
  • Celecox (celecoxib): Astellas/Pfizer
Patch/tape non steroid anti-inflammatory drugs; NSAIDs (Nov. 2008 version)
  • Naboal Tape (diclofenac): Hisamitsu
  • Voltaren tape (diclofenac): Novartis
  • Mohrus Tape (ketoprofen): Hisamitsu/Yutoku
  • Adofeed (flurbiprofen): Kaken
  • Seltouch (felbinac): Wyeth
  • Miltax (ketoprofen): Daiichi-Sankyo
  • Mohrus (ketoprofen): Hisamitsu
  • Loxonin PAP (loxoprofen): Daiichi-Sankyo
  • Naboal PAP (diclofenac): Hisamitsu
  • Loxonin tape (loxoprofen): Daiichi-Sankyo
Anti-allergy drugs
(Nov. 2008 version)
  • Zaditen (ketotifen): Novartis
  • Alesion (epinastine): Boehringer-Ingelheim
  • Ebastel (ebastine): Dainippon-Sumitomo/Meiji
  • Zyrtec (cetirizine): Daiichi-Sankyo/GSK/UCB
  • Claritin (loratadine): Schering-Plough/Shionogi
  • Talion (bepotastine besilate): Mitsubishi-Tanabe
  • Allelock (olopatadine): Sanofi-Aventis
  • Onon (pranlukast): Ono
  • Singulair (montelukast): Banyu
  • Kipres (montelukast): Kyorin
BPH / urinary disorder treatment drugs
(Nov. 2008 version)
  • Harnal (tamsulosin): Astellas
  • Flivas (naftopidil): Asahi-Kasei
  • Avishot (naftopidil): Schering-Plough
  • Urief (silodosin): Kissei
  • Urief (silodosin): Daiichi-Sankyo
  • Ebrantil (urapidil): Kaken
  • Prostal L (chlormadinone): Aska
  • Perselin (allylestrenol): Schering-Plough
  • Eviprostat (eviprostat): Nippon-Shinyaku
  • Cernilton (cernitin pollen extract): Fuso
Antiplatelets (Feb. 2009 version)
  • Bayaspirin (aspirin): Bayer
  • Panaldine (ticlopidine): Sanofi-Aventis
  • Pletaal (cilostazol): Otsuka
  • Plavix (clopidogrel): Sanofi-Aventis
  • Persantin (dipyridamole): Boehringer-Ingelheim
  • Epadel (ethyl icosapentate): Mochida
  • Opalmon (limaprost): Ono
  • Prorenal (limaprost): Dainippon-Sumitomo
  • Dorner (beraprost): Astellas/Toray
  • Procylin (beraprost): Kaken
Osteoporosis drugs (Feb. 2009 version)
  • Elcitonin (elcatonin): Asahi-Kasei
  • Alfarol (alfacalcidol): Chugai
  • Onealfa (alfacalcidol): Teijin
  • Rocaltrol (calcitriol): Chugai/Kyorin
  • Glakay (menatetrenone): Eisai
  • Bonalon 5mg (alendronate): Teijin
  • Bonalon 35mg (alendronate): Teijin
  • Fosamac 5mg (alendronate): Banyu
  • Fosamac 35mg (alendronate): Banyu
  • Actonel 2.5mg (risedronate): Eisai
  • Actonel 17.5mg (risedronate): Eisai
  • Benet 2.5mg (risedronate): Takeda
  • Benet 17.5mg (risedronate): Takeda
  • Evista (raloxifene): Eli-Lilly/Chugai

Some results (from BPH study Nov 2008):

  • Results showed that majority of the physicians were prescribing Harnal (tamsulosin), to their BPH patients. Harnal (tamsulosin) also had the highest prescription rates, with 36.7% of BPH patients being prescribed with this.
Breakdown of Methodology

  • In the next 6 months, approximately half the respondents using Urief (silodosin) estimated that their usage of Urief will increase. Interesting to note, approximately half of the respondents using Avishot (naftopidil) mentioned that their usage will decrease or that they will discontinue using Avishot in the next 6 months. This is most likely due to fact that the announcement of Avishot discontinuing its sales was reported during the fieldwork duration. Majority of respondents mentioned that they will most likely switch to Flivas (naftopidil) in place of Avishot.
Breakdown of Methodology

PRICE:

Antihypertensive drugs = 750,000 YEN All other disease topics = 500,000 YEN / per topic
  • *If payment is to be made domestically, additional 5% local tax will be added to the total fee